| Mercedes S W221 (2006 - 2013) | 3.0 V6 24 v 350 BlueTEC | 190 kW / 258 PS | 642 LS DE 30 LA | BOSCH | EDC17CP46 |
| Mercedes S W221 (2006 - 2013) | 3.0 V6 24 v 350 BlueTEC 4MATIC | 190 kW / 258 PS | 642 LS DE 30 LA | BOSCH | EDC17CP46 |
| Mercedes S W221 (2006 - 2013) | S300 3.0 V6 | 170 kW / 231 PS | M272E30 | BOSCH | ME9.7 |
| Mercedes S W221 (2006 - 2013) | S320 3.0 CDI | 173 kW / 235 PS | OM642DE30LA | BOSCH | EDC16CP31 |
| Mercedes S W221 (2006 - 2013) | S350 3.0 CDI Blue | 173 kW / 235 PS | OM642DE30LA | BOSCH | EDC17CP01 |
| Mercedes S W221 (2006 - 2013) | S350 3.0 CDI BlueTec | 190 kW / 258 PS | OM642DE30LA | BOSCH | EDC17CP01 |
| Mercedes S W221 (2006 - 2013) | S350 3.5 V6 | 200 kW / 272 PS | M272E35 | BOSCH | ME9.7 |
| Mercedes S W221 (2006 - 2013) | S400 3.5 V6 Hybrid | 205 kW / 279 PS | M272E35 | BOSCH | ME9.7 |
| Mercedes S W221 (2006 - 2013) | S420 4.0 CDI | 235 kW / 320 PS | OM629DE40LA | BOSCH | EDC16CP36 |
| Mercedes S W221 (2006 - 2013) | S450 4.6 V8 | 250 kW / 340 PS | M273E46 | BOSCH | ME9.7 |
| Mercedes S W221 (2006 - 2013) | S500 4.6 V8 TwinTurbo Blue | 320 kW / 435 PS | M278DE46AL | BOSCH | MED17.7.1 |
| Mercedes S W221 (2006 - 2013) | S500 5.5 V8 | 285 kW / 388 PS | M273E55 | BOSCH | ME9.7 |
| Mercedes S W221 (2006 - 2013) | S600 5.5 V12 TwinTurbo | 380 kW / 517 PS | M275KE55LA | BOSCH | ME2.8 |
| Mercedes S W221 (2006 - 2013) | S63 5.5 V8 TwinTurbo AMG | 400 kW / 544 PS | M157DE55LA | BOSCH | MED17.7.3 |
| Mercedes S W221 (2006 - 2013) | S65 6.0 V12 TwinTurbo AMG | 450 kW / 612 PS | M275KE60LA | BOSCH | ME2.8 |
